Contrave (naltrexone/bupropion)
Contrave is a prescription medicine that combines naltrexone and bupropion in a modified-release tablet. In Australia, it is approved for weight management in eligible adults when used alongside a reduced-calorie diet and increased physical activity.
The two active ingredients act on pathways in the brain involved in appetite, cravings and the reward response to food. The dose is usually increased gradually. A doctor reviews progress after treatment begins and decides whether the medicine is providing enough benefit to continue.
Contrave is not suitable for everyone. It may be unsafe for people with certain seizure disorders, uncontrolled high blood pressure, some eating disorders, or current opioid use, and it can interact with other medicines. Side effects can include nausea, constipation, headache, dry mouth and sleep problems. A doctor must assess the risks and explain how to take it safely.
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